P.1.i.013 No effect of TPH1, MAO-A, 5-HT1A and 5-HT2A gene variants on 5-HT1A binding potential in healthy subjects measured with PET

MDD[1]. Because of the cross-sectional design of the present study, it would remain unclear whether small WM habenular volume would be a vulnerability marker for treatment-resistance or whether a progressive atrophy would occur along the course of the illness (perhaps due to an overuse of the structure). The conclusions should be taken cautiously because patients were on medication. Additionaly, though reliability inter-rater coefficients were good, habenular nucleus is a little structure highly attached to surrounding nuclei, which could reduce the likelihood of finding further differences.