Efficacy and safety of the topical application of tranexamic acid in primary cementless hip arthroplasty: Prospective, randomised, double-blind and controlled study

Abstract Objective To evaluate the efficacy of topical tranexamic acid topical in cementless total hip arthroplasty from the point of view of bleeding, transfusion requirements and length of stay, and describe the complications of use compared to a control group. Material and methods A prospective, randomised, double-blinded and controlled study including all patients undergoing cementless total hip arthroplasty in our centre between June 2014 and July 2015. Blood loss was estimated using the formula described by Nadler and Good. Results The final analysis included 119 patients. The decrease in haemoglobin after surgery was lower in the tranexamic acid group (3.28 ± 1.13 g/dL) than in the controls (4.03 ± 1.27 g/dL, p  = 0.001) and estimated blood loss (1216.75 ± 410.46 mL vs. 1542.12 ± 498.97 mL, p p p Conclusions The use of topical tranexamic acid in cementless total hip arthroplasty results in a decrease in bleeding and transfusion requirements without increasing the incidence of complications.