[Effect of short-term intensive therapy with glimepiride and metformin in newly diagnosed type 2 diabetic patients].

Objective To evaluate the effect of short-term intensive therapy on blood glucose control,β-cell function,and blood lipid levels in newly diagnosed type 2 diabetic patients.Methods Out-patients with newly diagnosed type 2 diabetic patients were enrolled for intensive treatment with sulfonylureas and metformin for 12 weeks,and the therapeutic effect was evaluated.Results After the intensive treatment,FPG,2 hPG,and HbA1c decreased significantly(P0.01);HOMA-IR decreased and HOMA-B increased significantly(P0.01),and TG,CHOL,LDL decreased significantly(P0.01) after the treatment.Conclusion Short-term intensive treatment with glimepiride combined with metformin is safe and effective in newly diagnosed type 2 diabetic patients with HbA1c9%.