Bispecific antibody targeting human epidermal growth factor receptor

[Problem] To provide a bispecific antibody such as a bispecific antibody having a variety of high functionalities or a bispecific antibody produced using a novel antibody against human epidermal cell growth factor receptor 1 (EGFR), said novel antibody differing from antibody 528. [Solution] A bispecific antibody etc. against anti-human epidermal cell growth factor receptor 1 and CD3 that includes an L-chain variable region (2L; SEQ ID NO:2) and an H-chain variable region (2H; SEQ ID NO:4) of anti-human epidermal cell growth factor receptor 1 antibody 225, and an L-chain humanized variable region (OL; SEQ ID NO:6) and an H-chain humanized variable region (OH; SEQ ID NO:8) of anti-CD3 antibody (OKT3).