Alcohol dehydrogenase participating in butanol generation and application thereof

The invention relates to an alcohol dehydrogenase participating in butanol generation and application thereof. Particularly, from numerous genes participating in butanol generation, the inventor discovers that CA_C3375 alcohol dehydrogenase is a positive regulation and control gene for solvent biosynthesis (particularly butanol generation) in clostridium acetobutylicum; the yield of butanol in the clostridium acetobutylicum is obviously improved due to the existence of the gene; and the productivity of the butanol in the clostridium acetobutylicum can be obviously reduced due to the deletion of the gene. According to the invention, the clostridium acetobutylicum over-expressed by the CA_C3375 alcohol dehydrogenase for improving the productivity of the butanol is also constructed.