Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027

Fernando Seara,Pablo Nakagawa,Javier A Gomez,Guorui Deng,Julien A. Sebag,Sadashiva S. Karnik,Justin L. Grobe,Curt D. Sigmund

Abstract 104: DOCA Induced Natriorexigenic and Hypertensive Effects are Blunted by Central Infusion of AT1 Receptor Biased Agonist TRV120027

2018

Fernando Seara
Pablo Nakagawa
Javier A Gomez
Guorui Deng
Julien A. Sebag
Sadashiva S. Karnik
Justin L. Grobe
Curt D. Sigmund

TRV120027 (TRV) is biased agonist at the angiotensin AT1 receptor that activates the β-arrestin pathway, causing receptor internalization. AT1 signaling within the hypothalamus is required for the ...

Keywords:

Endocrinology
Diabetes mellitus
Agonist
Internal medicine
Medicine
Angiotensin II receptor type 1

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