Renal Effects of Metabolic Acidosis in the Normal Rat

Metabolic acidosis causes renal growth and proteinuria, and may contribute to the progression of CRF. This study assessed the effects of HCl-induced acidosis on the structure and function of normal kidneys. Acidosis was induced in 12 rats by dietary HC1. After 2 weeks, acidotic animals had higher kidney/ body weight ratios (0.47 ± 0.10 vs. 0.35 ± 0.10 g%, p