The question of the etiology of cervical lymphadenopathy in children: a systematic review of 527 cases in four studies

Purpose of the study. Determine the most common etiological factor in cervical lymphadenopathy in children according to research. Materials and methods. The research was searched in the Russian-language databases E-library and Cyberleninka in electronic form according to the following criteria: (1) any clinical trial or observational study, or cross-sectional case series with 10 or more subjects that included delineation of etiologies and/or associated conditions with lymphadenopathy; (2) patients aged 0 to 18 years with enlarged lymphoid tissue; (3) lymphadenopathy was confirmed by clinical evaluation; (4) the absence of specific excluded diagnoses. Results. Based on the search results in E-library and Cyberleninka, 4 articles were selected for review, matching the accepted criteria. These studies ranged in size from 67 to 255 subjects and had a combined total of 527 children. In the vast majority of cases (up to 90.0%) the cause of cervical lymphadenopathy in children is acute and chronic infectious diseases caused by herpes viruses and chlamydia.