An ancient protein-DNA interaction underlying metazoan sex determination

Mark W. Murphy,John K. Lee,Sandra Rojo,Micah D. Gearhart,Kayo Kurahashi,Surajit Banerjee,Guy-Andre Loeuille,Anu Bashamboo,Ken McElreavey,David Zarkower,Hideki Aihara,Vivian J. Bardwell

An ancient protein-DNA interaction underlying metazoan sex determination

2015

Mark W. Murphy
John K. Lee
Sandra Rojo
Micah D. Gearhart
Kayo Kurahashi
Surajit Banerjee
Guy-Andre Loeuille
Anu Bashamboo
Ken McElreavey
David Zarkower
Hideki Aihara
Vivian J. Bardwell

DMRT transcription factors, key regulators of metazoan sexual development, use a unique DNA binding mode critical for male-to-female sex reversal in humans.

Keywords:

DM domain
Transcription factor
HMG-box
Transcription (biology)
Protein–DNA interaction
DNA binding site
Molecular biology
Sex reversal
Biology
Genetics
Chromatin immunoprecipitation

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