S e n so ry D e fi c its a n d D istrib u te d H ie ra rc h ic a l D y sfu n c tio n in S c h iz o p h re n ia

Method: Event-related brain potentials were obtained from 50 schizophrenia patients and 21 healthy subjects in two conditions: a standard condition em ploying fixed differences between standard tones and pitch deviants and a novel individualized condition em ploying tones m atched to each individual’s tone-discrim ination threshold. The relationship am ong m easures was assessed by m ultiple regression analysis and structural equation m odeling. Results: In the standard fixed-deviance condition, schizophrenia patients showed deficits of large effect size in generation