Влияние наночастиц аморфного высокодисперсного кремнезема на систему крови и прооксидантно антиоксидантное равновесие тканей крыс

The comparative study on the effect of powders of amorphous highly dispersed SiO 2 nanoparticles (6–7 nm and 54–55 nm) and powder of standard largedisperse Lyuberets quartz PQ3 after single intratracheal administration in the dose of 50 mg in 3month experiment was carried out. During the experiment it was observed: eosinophilic reaction in peripheric blood; preferred formation of cell hypersensitivity reaction of emmediate action; disorders in prooxidantantioxidant balance in lungs, liver, erythrocytes and blood plasma; inhibition of lipid peroxidation in blood plasma and in lung and activation in liver; changes of antioxidant defence and cholinesterase activity. Damaging effects rising of the nanoparticles powders on the rats organisme by the end of the experiment was established. There was concluded that inhalanion of amorphous highly disperse SiO 2 nanoparticles into a worker’s organism in working conditions is dangerous for health.