In silico study shows arsenic induces P1B ATPase gene family as cation transporter by abscisic acid signaling pathway in seedling of Sorghum bicolor
2017
Human exposure to arsenic has increased rapidly with the expansion of industrial activity and its toxicity raises concerns for public health. Arsenic remediation by plants is regarded as suitable avenue to a safer environment. Transporters facilitate remediation by transporting negative ions, but the contribution of cationic transporters to anionic remediation has not been fully studied. To determine which transporter is involved in anion and cation toxicity, the P1B ATPase gene family and arsenic and cadmium expression network relations were navigated using text mining software. The extracted pathways were tested and analyzed in silico and by gene expression detection. The results show that many putative pathways exist between arsenic and cadmium and P1B ATPases to stimulate expression or inhibition of this family. This study showed that arsenic stimulates expression of the P1B ATPase transporter through the abscisic acid signaling pathway. This cascade, as the end section of the arsenic stimulation pathway on P1B ATPase, was improved and investigated. The experimental results show that expression of P1B ATPase increased in response to arsenic exposure in Sorghum bicolor. The putative network contained abscisic acid- and glucose-related pathways for arsenic and ZIP8-related pathways for cadmium.
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