Changes in the spectra of lipoproteins and phospholipids in the blood serum of patients with chronic renal failure placed on programmed hemodialysis

: Lipid metabolism was examined over time in patients with chronic renal failure placed on programmed hemodialysis. Altogether 22 patients were examined, with the times of dialysis treatment lasting from 6 months to 3 years. In addition to routine studies of lipid metabolism, this patients' group was assessed for changes in the spectra of lipoproteins and phospholipids. It was revealed that the content of total lipids in blood serum increased because of the rise of the content of cholesterol and triglycerides, the content of low density and very low density lipoproteins and the cholesterol coefficient of atherogeneity also rose. During typing according to Friedereichson IIA, IIB and IV hyperlipidemia types were defined. During typing of normolipidemia according to T. F. Pirogova and B. L. Dundure, alpha 3A and alpha 3C normolipidemia types were identified. According to diffuse electrophoresis in polyacrylamide gel, redistribution of lipoprotein fractions towards increase of low density lipoproteins was discovered, accompanied by the reduction of the percentage of phospholipids in these fractions.