Adapter proteins regulate insulin resistance and lipid metabolism in obesity

Insulin resistance and dysregulated lipid metabolism are major causes of type 2 diabetes. Insulin and inflammatory signal pathways play key roles in insulin resistance and fat accumulation. Specifically, adapter proteins transduce signals from insulin or cytokine receptors to the downstream pathways and may contribute to insulin resistance and disordered lipid metabolism in obesity and type 2 diabetes. Here, the recent advances in understanding the roles of adapter proteins in insulin resistance and lipid homeostasis are discussed.