Palladium-Catalyzed C-P Bond Activation of Aroyl Phosphine Oxides without the Adjacent “Anchoring Atom”

Abstract A novel palladium-catalyzed decarbonylation of aroyl phosphine oxides to prepare phosphine oxides from carboxylic acids is developed. Without the adjacent “anchoring atom”, the challenging C–P bond activation is achieved in high selectivity. The disclosure of this reaction provides a new example of C–P bond activation and helps to extend the understanding of the property of C–P bond.