Indium Trichloride (InCl3) Catalyzed Synthesis of Fused 7‐Azaindole Derivatives Using Domino Knoevenagel—Michael Reaction.

An efficient and high yielding methodology developed for the synthesis of fused 7-azaindole derivatives via one pot multicomponent assembly process of cyclic 1,3-dicarbonyls with substituted aldehydes and 5-amino-1-tert-butyl-1H-pyrrole-3-carbonitrile. The transformation occurs via domino Knoevenagel- Michael reaction followed by intramolecular cyclization in the presence of catalytic amount of InCl3 (10 mol %). Mild reaction conditions, easy isolation of products, and good to excellent yields in a shorter period of time are the silent features of present methodology. Structures of all the newly prepared compounds have been corroborated by various spectroscopic methods.