Lamellar macular hole after ranibizumab in a patient with neovascular age-related macular degeneration and vitreomacular adhesion.

PURPOSE: To report a case of formation of lamellar macular hole after ranibizumab in a patient with neovascular age-related macular degeneration and vitreomacular adhesion. METHODS: A 76-year-old man with neovascular age-related macular degeneration and vitreomacular adhesion was studied by biomicroscopy, fluorescein angiography, and optical coherence tomography and was treated with intravitreal ranibizumab. RESULTS: The neovascular membrane regressed and the patient developed lamellar macular hole when seen 1 month after the ranibizumab injection. CONCLUSION: Persistent vitreomacular traction along with the decrease in retinal edema after intravitreal ranibizumab could have contributed to the formation of lamellar macular hole. Thus, in cases with retinal edema and vitreomacular adhesion, this event after anti-vascular endothelial growth factor therapy should be considered, especially if vision does not improve despite resolution of edema.