Preparation and Study of Core Shell Fe3O4/Au Nanoparticles for Traceability of Blood Vessels and Biosensing by Surface Enhanced Raman Spectroscopy

Fe 3 O 4 /Au core-shell nanoparticles have been prepared using reverse micelle synthesis with the aim of studying the traceability of blood vessels and allow biosensing through surface enhanced Raman spectroscopy. The shell provides protection against oxidation, plasmon properties and prevents aggregation of the magnetic nanoparticles. A solution of Fe 3 O 4 /Au core-shell nanoparticles in fluorescence has been injected into fresh ex-vivo animal tissues to check the traceability of blood vessels. Optical properties of the tissues in the UV-Vis-NIR have been explored on both fresh and injected tissues to prove the penetration of Raman excitation sources through the dermis and the entire sequence of the skin layers. Postbariatric surgery as well as rapid diagnosis on circulatory issues are examples of future applications.