Effects of the neuropeptide PLG (L-prolyl-leucyl-glycinamide) on writing pressure and speed in healthy subjects.

: There has been accumulating evidence that PLG influence behavior in humans after peripheral administration. In a randomized double blind study with 10 healthy male subjects in each group, the effect of 25 mg PLG i.v. on writing regulation was investigated and computer evaluated. The writing pressure test was selected as a sensitive parameter to ascertain an effect of PLG on motor behavior. As compared to the placebo group, PLG effects an increase of writing time and a reduction of writing pressure. The results suggested an peptide effect on writing performance in healthy subjects.