Nuclear medicine progress report, quarter ending September 30, 1983

The results of a systematic evaluation of adsorbents for potential use in the /sup 191/Os//sup 191m/Ir medical radionuclide generator are described. The adsorbents included 39 inorganic materials broadly classified as oxides, antimonates, ferro-ferricyanides, phosphates, sulfides, and miscellaneous materials, and the organic anion-exchanger AGMP-1. The uptake of /sup 191/Os in oxidation states (VI), (IV) and (III) was measured and the adsorbents having a high /sup 191/Os uptake were evaluated for /sup 191m/Ir elution yield using three physiologically compatible eluents. The synthesis and evaluation of a variety of radiolabeled fatty acids as potential myocardial imaging agents has continued. Because of interest in the use of radiobrominated fatty acids for positron emission tomographic evaluation (PET) of myocardial disease, several bromine-82 labeled agents were prepared and studied. These include both cis (Z) and trans (E) 18-(/sup 82/Br)bromo-5-tellura-17-octadecenoic acid and 17-(/sup 82/Br)bromo-9-telluraphetadecanoic acid. A variety of telluraheptadecanoic acid (THDA) analogs and other fatty acids have been evaluated using the rat myoblast assay system. In the most recent studies 11-THDA, 18-bromo-9-THDA and 15-(iodophenyl)-3-R,S-methylpentadecanoic acid (BMIPP), were evaluated for myoblast uptake and retention.