Oxygen Supply and Microcirculation of the Beating Dog Heart after Haemodilution with Fluosol DA20

Previous studies on local tissue oxygen supply after haemodilution with the colloidal perfluorocarbon Fluosol DA20% (FDA20%) carried out in the liver (Hoper et al., 1982), pancreas, kidney and skeletal muscle (Kessler et al., 1982), and the heart (Vogel et al., 1983; Kessler et al., 1983) have demonstrated that an improvement in local tissue oxygen supply was observed which was greater than could be explained simply in terms of the increased quantity of oxygen delivered by the fluo-rocarbon. It was evident that changes in flow occured (Hoper et al., 1982), probably at the microcirculation 1evel.