Separate Renal Function Evaluation by DMSA

Radioisotope exploration of the kidneys allows separate renal function determination without retrograde catheterization (Taylor and Nelson 1979). Dimercaptosuccinic acid (DMSA) is a chelate which was first used as a protective agent against irradiation, in the deintoxication of heavy metals, and in the treatment of schistomiasis (Cannava and Cugarra 1961; Fraga de Azevedo and Braganca 1966). DMSA labeled with technetium 99m (DMSA sn 99Tc) was proposed to obtain images of renal parenchyma (Enlander et al. 1974; Lin et al. 1974; Arnold et al. 1975; Mandmaker et al. 1975; Vanlic Razumedic and Gorkic 1976; Daly et al. 1977); afterwards it was used as an index for separate renal function (Moretti et al. 1975; Raynaud et al. 1975; Dumery et al. 1977; Rapin et al. 1979).