Fentanyl enhances the excitability of rapidly adapting receptors to cause cough via the enhancement of histamine release in the airways
2013
Background
Although the mechanism of fentanyl-induced cough is unclear, several lines of evidence suggest that allergic mediators, such as histamine, may play a role in the production of fentanyl-induced coughs. The aim of this study was to explore the effects of fentanyl on cough sensitivity to inhaled citric acid and on histamine release in BALF in mice.
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