Prevalent and Rare Mutations in the Gene Encoding Filaggrin in Japanese Patients with Ichthyosis Vulgaris and Atopic Dermatitis

CXCL8 in the NOD1 shRNA-expressingcells is mediated by such receptors.In summary, to our knowledge this isthe first report demonstrating that theintracellular receptor NOD1 is func-tional expressed in human keratino-cytes, suggesting that NOD1 may beinvolved in cutaneous innate immunity.Further studies are needed to under-stand the contribution of intracellularinnate immune receptors to cutaneoushost defense.