Presence of the Two Growth Hormone Receptor Messenger RNA Isoforms in Human Breast Cancer

By Northern blot analysis (Fig. 1) of total RNA prepared from breast cancer biopsies and from breast cancer cell lines, GH receptor cDNA probe identified a rnRNA of 4.7 kb, which is similar in size to that previously reported in human liver (6). This transcript was clearly observed in the T-47D and MCF7 cells; it was not the case in the MDAVol. 6, 477-483, April 1995 Cell Growth & Differentiation 477