Divergent Gemycircularvirus in HIV-Positive Blood, France.

To the Editor: Gemycircularviruses are a group of recently discovered single-stranded DNA viruses, found initially in fungi in 2010 (1). These “myco-like” viruses have a genome ranging from 2.1 to 2.3 kb, containing 2 opposite open reading frames that probably code for a capsid protein (CP) and a spliced replication-associated protein (Rep). Related viruses have been subsequently identified in animal blood and fecal matter, raw and treated sewage, and insects and plant material, suggesting that gemycircularviruses may represent a large group of viruses exhibiting considerable genetic diversity (2–8). The presence of these viruses was recently extended to humans after gemycircularvirus sequences were identified in human blood and brain tissue (multiple sclerosis patient), cerebrospinal fluid, and fecal matter (8,9).