Anaphylactic reaction to cinoxacin: Report of one case associated with inferior acute myocardial infarction

Cinoxacin is an oral symthefic antibacterial agent, of the second generation quinolones group with excellend efficacy in respiratory, intra-abdominal, pelvic, and skin and soft tissue injections. Overall, quinoiones are well tolerated drugs, ulthough phototoxicity and photoallergenicity is well demonstrated experimentally. In this report we show you a case of a man who presented a anaphylactic reaction associated with myocardial infarction, after taking a capsule of cinoxacin. We suppose that there is a direct participation of the heart in anaphylactic reactions, because attivated mast-cells mediators can determine cardiovascular effects. Then performed double-blind placebo controlled challenge test with an alternative drug we did not observe any adverse immediate or late adverse reaction to this drug.