Kit formulation for 99mTc-labeling of HYNIC-βAla-Bombesin((7-14)).
2012
Abstract Bombesin (BBN) is a tetradecapeptide that binds specifically to gastrin-releasing peptide receptors. Several forms of cancer, including lung, prostate, breast, and colon express receptors for bombesin-like peptides. Radiolabeled BBN analogs with a high affinity for these receptors might be used for scintigraphic imaging. Kit formulations for labeling these molecules are important for routine preparation. A freeze-dried kit for labeling HYNIC-βAla-Bombesin (7–14) with technetium-99m was prepared, and its storage stability was evaluated by in vitro and in vivo assays.
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