Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

Kentaro Futatsugi,Aaron C. Smith,Meihua Tu,Brian Raymer,Kay Ahn,Steven B. Coffey,Matthew S. Dowling,Dilinie P. Fernando,Jemy A. Gutierrez,Kim Huard,Jayasankar Jasti,Amit S. Kalgutkar,John D. Knafels,Jayvardhan Pandit,Kevin D. Parris,Sylvie Perez,Jeffrey A. Pfefferkorn,David Price,Tim F. Ryder,Andre Shavnya,Ingrid A. Stock,Andy Tsai,Gregory J. Tesz,Benjamin A. Thuma,Yan Weng,Hanna M. Wisniewska,Gang Xing,Jun Zhou,Thomas V. Magee

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose.

2020

Increased fructose consumption and its subsequent metabolism have been implicated in metabolic disorders such as non-alcoholic fatty liver disease and steatohepatitis (NAFLD/NASH) and insulin resis...

Keywords:

Insulin resistance
Insulin
Internal medicine
Endocrinology
Increased fructose
Fructose
Metabolism
Chemistry
Fatty liver
Overconsumption
Steatohepatitis

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