Immobilization of novel inorganic nano-complexes onto MWCNTs nano- materials as a novel adsorbent and an anti-inflammatory therapy in induced model of rheumatoid arthritis

Novel supported inorganic metal nano-complexes of Ag(I) and Co(II) derived from 4-amino-N-(4-methylpyrimidin-2-yl) benzene sulfonamide (SulMer) were synthesized using olive leaf extract as reducing agent via grinding as well as microwave methods. The prepared samples denoted as comp1-6. The surface morphology of synthesized nanomaterials were analyzed by C, H, N, S analysis, Fourier-transform infrared spectroscopy, UV visible spectroscopy, Proton and Carbon Nuclear Magnetic Resonance,, SEM, TEM, TGA, and X-ray Powder Diffraction analysis. The data revealed that all the synthesized complexes exhibited 1:1 metal to ligand ratio with a coordination number of 4 or 6. The mean particle size of nanomaterials samples were with an average size of 25 - 35 nm. XRD patterns indicated a crystalline nature for the complexes. The supported inorganic metal nano-complexes displayed good activity for the adsorptive removal of Direct red 81 (DR-81) from aqueous solutions. On other hand, the studying of the effect of the supported metal nano- complexes on the immune system of the body was determined and how to use these anti-inflammatory compounds to treat many autoimmune diseases, most notably rheumatoid arthritis. Experimental model for arthritis can be induced using Freund's complete adjuvant (CFA). It was shown that the supported complex offer several advantages such stability, eco- friendly, simple experimental conditions, short time reaction, and easy work- up.