NO-donating aspirin inhibits intestinal carcinogenesis in Min (APCMin/+) mice

Abstract The chemopreventive effect of nitric oxide-releasing aspirin (NO-ASA) against gastrointestinal tumorigenesis was evaluated in Min ( APC Min /+ ) mice. NO-ASA consists of a traditional ASA that bears covalently attached to it an NO-releasing moiety. Four groups ( N =10) of six-week-old female C57BL/6J APC Min /+ and the corresponding C57BL/6J +/+ wild type mice were treated either with vehicle or NO-ASA 100 mg/kg/day intrarectally for 21 days. There were no signs of overt toxicity including gastrointestinal toxicity from NO-ASA. Vehicle treated Min mice had 24.7 ± 3.8 tumors (mean ±  SEM) and NO-ASA treated Min mice had 10.1 ± 1.4 tumors (59% reduction; P Min mouse and suggest that this agent merits further evaluation as a chemopreventive agent against colon cancer.