Analyzing Microarray Data with the Generative Topographic Mapping Approach

The Generative Topographic Mapping (GTM) approach of Bishop et al. (1998) is proposed as an alternative to the Self-Organizing Map (SOM) approach of Kohonen (1998) for the analysis of gene expression data from microarrays. It is applied exemplarily to a microarray data set from renal tissue and the results are compared with those derived by SOM. Furthermore, enhancements for the application of the GTM methodology to microarray data are made.