New Plexin polypeptide and the DNA encoding it, and use thereof

The present invention relates to in angiogenesis and its function conservation of various organs, angiogenesis at the time of various organs or cancer and organ regeneration, to the proliferation and differentiation and the function conservation of cells of various organs, or aging, related to the dysfunction prophylactic, therapeutic agent, or a gene containing a useful novel DNA and the DNA screening such test agent, recombinant proteins comprising the novel polypeptide and the polypeptide encoded by the DNA, provided antibodies against novel polypeptides to it. A DNA consisting of the following (a) or nucleotide sequence encoding the polypeptide of (b): (a) SEQ ID NO: 1, amino acid sequence identical or substantially represented by SEQ ID NO: 15 or SEQ ID NO: 18 a polypeptide consisting of a portion or all of the identical amino acid sequence to, (b) SEQ ID NO: 1, an amino acid sequence shown in SEQ ID NO: 15 or SEQ ID NO: 18, a part of amino acids are deleted, substituted or added consists of the amino acid sequence, a polypeptide having a polypeptide substantially the same biological activity of (a).