Dragmacidol A and Dragmacidolide A from the Australian Marine Sponge Dragmacidon australe.

Two new secondary metabolites, the xylerythrin derivative dragmacidol A (1) and the steroid dragmacidolide A (2), were isolated from a specimen of the marine sponge Dragmacidon australe, collected off the coast of the Whitsunday Islands in Queensland, Australia. Their structures were fully characterized via analysis of 1D/2D NMR and MS data. The proton-poor structure of 1 was also supported through successful 13C DFT-NMR calculations. The isolation of these two metabolites from this sponge genus is quite unusual, given that previous reports of Dragmacidon secondary metabolites have been dominated by indole and β-carboline alkaloids.