Dihydropyrimidine dehydrogenase gene (DPYD) polymorphism among pts with 5-FU/capecitabine (CAP)-related adverse events (AEs): Experience of 2 decades.

2576Background: DPYD gene encodes DPD, the rate-limiting enzyme responsible for catabolism of 5-FU and is responsible for > 85% of 5-FU elimination. Deficiency of DPD due to DPYD polymorphism gives...