Amlodipine vs Nifedipine Retard

Two groups of 30 outpatients took part in a 3-month study designed to compare the efficacy and tolerability of the dihydropyridine calcium antagonists amlodipine and nifedipine retard in patients with mild to moderate essential hypertension. Data from 24-hour ambulatory blood pressure monitoring confirmed that both drugs produced good blood pressure control, although more significant and persistent reductions were observed in amlodipine recipients. This superiority may be due to the sustained plasma concentrations produced by this drug. Patients treated with amlodipine also experienced fewer adverse events than the nifedipine group.