Serum transaminases at presentation and association with acute dialysis in children with hemolytic uremic syndrome

Background: To determine whether serum transaminases at presentation predict the need for dialysis in children with hemolytic uremic syndrome (HUS). Methods: Single-center, retrospective chart review of pediatric patients with HUS. Data collected included demographics, clinical and laboratory parameters and need for dialysis. These factors were compared between two groups - 9dialysis9 vs 9no dialysis9. Continuous data were compared using a t-test whereas categorical data were compared by Chi-Square. Multivariate logistic regression was performed on a prior set of variables to determine if serum transaminases independently predict the need for dialysis. Results: A total of 70 children were included in the study, of which, 39/70 (27%) received dialysis. No dialysis group had a higher proportion of Caucasians compared to the dialysis group (73.9% Dialysis vs 93.6% No dialysis). The only clinical sign at admission associated with dialysis was reduced urine output (56.4% vs 16.1%, p 2 x upper level of normal the need for dialysis is very high.