Sex-dependent association of ACE (I/D) polymorphism with Meniere's disease

Abstract Background Meniere's disease is an inner ear disorder presenting with recurrent episodic vertigo, fluctuating sensorineural hearing loss, tinnitus, and aural fullness as its main symptoms. Previous studies have demonstrated the role of blood pressure in Meniere's disease. The purpose of this study was to determine the role of ACE, rs4646994 I/D polymorphism in Meniere's disease. Methods and materials In this case-control study, 67 individuals with Meniere's disease and 100 healthy individuals as a control group were enrolled. Patients DNA samples were extracted from the blood by the phenol-chloroform method. The frequency of genotypes were determined by polymerase chain reaction (PCR) technique. Results The genotypes and allele frequencies were not significantly different between the studied populations (p > .05). There was significant differences for distribution of I/D genotype between females and males (p  Conclusions This study demonstrates the gender association of ACE rs4646994 polymorphism with Meniere's disease in an Iranian population.