STOMACH-SPECIFIC MUCOADHESIVE NANOPARTICLES AS A CONTROLLED RELEASE DRUG DELIVERY SYSTEM

In recent years scientific and technological advancement have been made in the rate controlled oral drug delivery system by overcoming physiological adversities, such as short gastric residence time (GRT) and unpredictable gastric emptying time (GET). So an interest increased towards novel dosage forms, that can retained in the stomach for a prolonged and predictable period of time. The concept of such novel dosage forms is to decrease the GI transit rate of the drug delivery system by attachment to the mucus layer, thereby increasing the overall time for drug absorption. A further advantage of such delivery systems is that the drug no longer must diffuse through the luminal contents in order to reach the mucosal epithelium. Various polymers have been used in the formulation of stomach specific mucoadhesive nanoparticles for drug delivery to increase therapeutic benefit, while minimizing side effects. Here we have discussed about concept of gastric emptying, absorption window, potential drug candidates, technological development evaluation and applications for stomach-specific mucoadhesive nanoparticles. Marketed products for oral nanoparticulate drug delivery systems are also discussed in this review.