Abstract P053: Modifiable Risk Factors for Prevention of Cardiovascular Disease and Mortality in Middle-Aged Women: Systematic Review and Meta-Analysis

Introduction: Modifiable risk factors can play major role to prevent adverse outcomes but their specific contribution in this phase of women's life course remains unclear. Hypothesis: We assessed evidence on the effects of different modifiable risk factors on preventing CV events and mortality in middle-aged women. METHODS: Systematic searches of medical databases (Pubmed, Embase, Medline, WoS, Lilacs, Scielo, PsycInfo, Popline and Google Scholar), reference lists of relevant studies and correspondence with authors in the field were conducted up to August 11th 2014. We selected and extracted data from cohort studies, which reported the association between leisure physical activity (LPA) levels and coronary heart disease (CHD),stroke, CV deaths and all-cause mortality in women (>40 years old). For PA we calculated study specific relative risks (RR) comparing highest to lower exposure categories in each study. Lower categories of LPA were equivalent to ≤ 3 METS h/week, higher categories of LPA were equivale...