Implementation of a cluster randomized controlled trial: identifying student peer leaders to lead E-cigarette interventions. (Special Issue: The development and evaluation of novel, youth E-cigarette prevention and cessation programs.)

E-cigarette use has been increasing among middle school students Intervention programs to prevent e-cigarette initiation administered by authority figures are met with more resistance from youth compared to peer-led programs Therefore, this study aimed to assess the feasibility, acceptability, and implementation process of using social network analysis (SNA) to identify student peer leaders in schools and train them to deliver e-cigarette prevention programming to their peers Nine schools were recruited to participate in the study during the 2019-2020 school year Schools were assigned to one of three conditions: (1) expert;(2) peer-random (selected peer-leaders would teach to random students);and (3) peer-fixed (selected peer-leaders would teach to assigned students based on nominations) Study participation varied by day due to school attendance, with 686 participants at baseline and 608 at posttest Almost all students who did not complete the study resulted from the interruption of schools being closed due to COVID-19 Implementation issues fell into three categories: (1) scheduling, (2) day-of logistics, and (3) student group dynamics Overall, the results showed positive satisfaction among teachers, who unanimously found the program appropriate for the grade-level and that peer-leaders worked well within their groups Peer-led students - both random and assigned - reported having more fun and willing to tell friends to try the program compared to expert-led students This study demonstrated the feasibility of implementing a peer-led e-cigarette prevention program for 6th grade students, using SNA to provide intervention rigidity and validity