CD20-Positive and CD4/CD8-Double-Negative Peripheral T-Cell Lymphoma of Spleen Complicated with Severe Disseminated Intravascular Coagulation and Enteropathy

A 71-year-old woman presented with massive splenomegaly. Open splenectomy was performed, and the diagnosis of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), was made, with a characteristic immunophenotype of CD3, CD4, CD8, T-cell receptor (TCR)ab, and TCRgd. After splenectomy, she suffered abrupt exacerbation of the lymphoma with disseminated intravascular coagulation and enteropathy. Although chemotherapy was started, her medical condition did not improve and she died a week later. Postmortem reevaluation of the pathological specimen confirmed her diagnosis as CD20 PTCL-NOS. Although it is a rare disease entity, CD20 T-cell lymphoma can demonstrate aggressive clinical behavior. 〔J Clin Exp Hematopathol 52(2) : 133-136, 2012〕