Identification of mediator specific Cardiovascular waveforms using a back propagation neural networks

Abstract A diverse milieu of inhaled substances induce the release of endogenous mediators. These mediators are responsible for the symptoms manifested by a wide spectrum of allergic and toxic scenarios. Platelet activating factor (PAF) and prostaglandin H 2 analog (PGH) are two such mediators. A sheep was exposed to varied doses of PAF and PGH. Five parameters were monitored to characterize the cardiovascular response. A back propagation network was used to analyze the response data. The network was trained using three different groups of 21 of the 28 total data sets. In each case, seven data sets were withheld from training and used to assess the performance of the networks. In each case, the back propagation network (BPN) qualitatively and quantitatively (error