Assessment of oxidative stress and inflammation inprediabetes—A hospital based cross-sectional study
2016
Background and aim: Prediabetes is associated with dysglycemia, obesity, inflammation and endothelial
dysfunction, contributing towards the pathogenesis of cardiovascular diseases rendering them
vulnerable for the same. The current study intended to explore the risk of cardiovascular disease
(CVD) related with prediabetes by assessing oxidative stress and inflammation using serum interleukin-
6 (IL-6), myeloperoxidase (MPO) and urine microalbumin (MA) and their correlation with fasting plasma
glucose (FPG) and physical measurements.
Materials and methods: Based on FPG values, 80 subjects were grouped into prediabetes and healthy
controls. IL-6 and MPO were estimated in serum sample whereas MA was estimated in random urine
sample.
Results: Prediabetes group had significantly increased (p < 0.05) mean anthropometric measurements
and IL-6, MPO and MA as compared to healthy controls. MPO had significant correlation with FPG (r-
0.388) in the prediabetes group. IL-6 and MPO showed a positive correlation with body mass index (BMI
(r-0.339, r-0.327)), waist circumference (WC (r-484, r-0.493)) and waist-to-hip ratio (WHR (r-0.430, r-
0.493)) while MA did not correlate with FPG and anthropometric measurements.
Conclusion: This study suggests that prediabetes is associated with central adiposity, inflammation and
oxidative stress predisposing them to an increased risk for CVD.
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