Is JmjC Oxygenase Catalysis Limited to Demethylation

Histone modifications are of central importance in the regulation of transcription.1,2 Whilst histone acetylation is in general transcriptionally activating, histone lysine methylation can be activating or inhibitory depending on factors including the site and type of modification. Therefore, modulation of histone methylation is being pursued for the therapeutic regulation of gene expression.3–6