Assessment of the diagnostic significance of modern biomarkers and hemodynamic alterations in workers of vibration-hazardous occupations

Introduction. One of the most significant tasks in modern labor medicine is to reduce the indicators of early disability in persons in contact with harmful and dangerous factors of the production environment. The issue of finding markers of early preclinical manifestations of vibrational disease and establishing comorbid conditions that are prognostically unfavorable for the course of the underlying occupational disease remains relevant. The purpose of the study is assessment of diagnostic significance of current neurospecific biomarkers and hemodynamic changes in workers of the profession related to vibration. Material and methods. The results of two studies were the basis for this work. The first, aimed at determining the concentration of neurospecific markers in the blood of miners, includes 154 working vibration hazardous professions. At the same time, groups were identified depending on the type of exposure to vibration: total (69 workers), local (24 workers) and combined general and local (61 miners) and control group of workers not in contact with vibration (49 people). The second study was performed to assess the change in hemodynamic parameters among 216 industrial workers, of which 114 people were in contact with vibration generating equipment, and 102 workers were included in the control group. Results. Data from the first study showed an increase in the titer of neuron-specific indicators, mainly protein S100B, depending on the type of exposure vibration and its seniority dose. The second study results indicated an increase in systolic blood pressure and total peripheral vascular resistance in miners under exposure to vibration factor. Conclusion. The results of both studies suggest that hemodynamic disorders and changes in the performance of neuro specific proteins may be interconnected. It seems advisable to continue the study in workers in vibrant occupations with comorbid pathology.