Biochemical markers of endothelial dysfunction and cardiovascular system state in patients with occupationai bronchopulmonary diseases

: The article presents results of study concerning biochemical markers of endothelial dysfunction and structural changes in cardiovascular system of aluminium production workers with initial and advanced symptoms of occupationally related bronchopulmonary diseases. Common pathogenetic traits of cardiovascular diseases with initial and advanced symptoms of occupationally related bronchopulmonary diseases are disordered regulation of vascular tone due to nitrogen and plasmin, atherosclerotic plaques formation and changed cardiomyocytes function. Individuals with initial symptoms of occupationally related bronchopulmonary diseases are characterized by increased cardiomyocytes apoptosis due to circulatory disorders. Mechanisms of cardiovascular diseases for advanced symptoms of occupationally related bronchopulmonary diseases are related to disordered regulation of cellular hemostasis by nitrogen oxide and plasmin, changed regulation via b-adrenoreceptors and altered cardiomyocytes metabolism.