E-cadherin/beta-catenin expression pattern, clinicopathological parameters and prognosis in gastric carcinomas

Objectives: This study aimed to evaluate the expression pattern of some markers (E-cadherin and â-catenin) related to cellular adhesion and their relationship with histological tumor type according to Lauren's system, clinicopathological features and patient survival. Material and Methods: We did immunohistochemical analysis in a retrospective series of 446 gastric carcinomas using tissue microarray method (TMA). Clinicopathological features and overall survival data of all patients were retrospectively reviewed from hospital records. For all statistical analyses, p