An ID2-dependent mechanism for VHL inactivation in cancer

Lee Sb,Frattini,Mukesh Bansal,Angelica Castano,Sherman D,Hutchinson K,Jeffrey N. Bruce,Andrea Califano,Liu G,Timothy Cardozo,Antonio Iavarone,Anna Lasorella

An ID2-dependent mechanism for VHL inactivation in cancer

2016

Lee Sb
Frattini
Mukesh Bansal
Angelica Castano
Sherman D
Hutchinson K
Jeffrey N. Bruce
Andrea Califano
Liu G
Timothy Cardozo
Antonio Iavarone
Anna Lasorella

HIFα transcription factors are highly expressed in cancer stem cells from glioma; DYRK1 kinases inhibit the protein ID2 to modulate the level of HIF2α and the tumorigenic properties of glioblastoma-associated cancer stem cells.

Keywords:

Transcription factor
Glioma
Ubiquitin
Phosphorylation
Cancer
Cancer research
Cancer stem cell
Kinase
Biology
Protein-Serine-Threonine Kinases
Ubiquitin ligase complex
Cullin
DYRK1B
Cancer cell

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