Synthesis and Sar of Thiophene Containing Kinesin Spindle Protein (Ksp) Inhibitors.
2007
We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for other known KSP inhibitors.
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KQI